Enzo Agostinelli
Sapienza University of Rome, Italy
Kazuei Igarashi
Chiba University, Japan
E. Agostinelli (Italy)
G. Canettieri (Italy)
S. Fujiwara (Japan)
S. Gilmour (USA)
K. Igarashi (Japan)
A. Kaiser (Germany)
A.R. Khomutov (Russia)
H.J. Lin (Taiwan)
A. Mattoo (USA)
T. Oka (Japan)
O. Phanstiel (USA)
A. Toninello (Italy)
F. Vianello (Italy)
K.T. Wilson (Wilson)
E. Agostinelli, R. Bordone, G. Canettieri, S. Coni, L. Di Magno, C. Fiorucci, D. Ivy, A. Montella, R. Pellegrino, A. Ragno, L. Rutigliano, T. Tahara.
Enzo Agostinelli
Department of Sensory Organs,
SAPIENZA University of Rome
University Hospital “Policlinico Umberto I“
Viale del Policlinico 155, I-00161 Rome, Italy
Mobile: +39 335 7072166
Phone Hospital: +39 (0)6 49976857 (Office/lab: 76857)
e-mail : enzo.agostinelli@uniroma1.it
e-mail: polyfoundation2017@gmail.com
Updated July 18th, 2022
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| 1:30pm 5:30pm |
Registration at the Grand Hotel Duca d’Este (Tivoli) |
| 5:30pm 6:00pm |
Opening Ceremony |
E. Agostinelli, Rome, Italy
K. Igarashi, Chiba, Japan
U. Bachrach, Jerusalem, Israel
| 6:00pm 7:00pm |
Opening Lectures | Session leaders: E. Agostinelli (SAPIENZA University of Rome, Italy) | U. Bachrach (Hebrew University, Israel) |
|---|---|---|---|
| 6:00pm 7:00pm |
[PL 01] | K. Igarashi (Chiba University and Amine Pharma, Japan) | Molecular mechanisms of cell and tissue toxicity caused by acrolein |
| 6:30pm 7:30pm |
Registration at the Grand Hotel Duca d’Este (Tivoli) | ||
| 7:30pm 10:30pm |
Welcome dinner at the Grand Hotel Duca d’Este (Tivoli) |
| 9:00am 10:00am |
Session 1: POLYAMINES IN CELL GROWTH AND DIFFERENTIATION | Session leader: T. Oka (Wakunaga Pharmaceutical Co.Ltd, Japan) | |
|---|---|---|---|
| 9:00am 9:30am |
[L 02] | A. Zabala Letona (Center for Cooperative Research in Biosciences, Spain) | Emerging roles of polyamine metabolism in prostate cancer |
| 9:30am 10:00am |
[L 03] | M. Pujana Vaquerizo (Center for Cooperative Research in Biosciences, Spain) | Analysis of the molecular and biological consequences of GC7 treatment in prostate cancer |
| 10:00am 12:40pm |
Session 2: eIF5A AND TRANSLATION | ||
|---|---|---|---|
| 10:00am 10:35am |
[PL 04] | A. Kaiser (University of Duisburg-Essen, Germany) | Investigation of an allosteric deoxyhypusine synthase inhibitor in P.falciparum |
| 10:35am 11:05am |
Coffee break | ||
| 11:05am 11:40am |
[PL 05] | K.T. Wilson (Vanderbilt University Medical Center, USA) | Protective Role of Spermidine and Hypusination in Colitis and Colitis-associated Colon Carcinogenesis |
| 11:40am 12:10pm |
[L 06] | G. Canettieri (Sapienza University of Rome, Italy) | A novel interplay between polyamines, EIF5A and MYC in colorectal cancer |
| 12:10pm 1:00pm |
[L 07] | A.Szepesi (University of Szeged, Hungary) | Connection between GABA and hypusination process of Arabidopsis thaliana seedlings influencing polyamine catabolism. |
| 1:00pm 2:30pm |
Lunch | ||
| 3:30pm 5:00pm |
Poster session and coffee break |
| 5:00pm 6:35pm |
Session 3: POLYAMINES AND PHYSIOLOGY | Session leader: K.Igarashi, (Chiba University and Amine Pharma, Japan) | |
|---|---|---|---|
| 5:00pm 5:35pm |
[PL 08] | K. Kashiwagi (Chiba institute of science, Japan) | Regulation of gene expression through translational stimulation of histone modifying enzymes by polyamines |
| 5:35pm 6:05pm |
[L 09] | S. Coni (Sapienza University of Rome, Italy) | Locomotor function in Drosophila Melanogaster is controlled by a CNBP/ODC/polyamines translational axis |
| 6:05pm 6:35pm |
[L 10] | T. Sieckmann (Institute of translational Physiology, Germany) | Dysregulation of the polyamine system in favor of its catabolism is a common mechanism after kidney injury |
| 7:00pm 8:15pm |
Dinner | ||
| 8:30pm 12:00am |
Rome by night |
| 9:00am 12:40am |
Session 4: POLYAMINES IN HUMAN HEALTH: IN CANCER AND OTHER DISEASES. THERAPEUTIC APPLICATIONS | Session leader: D. A. Spandidos (University of Crete, Greece) | |
|---|---|---|---|
| 9:00am 9:35am |
[PL 11] | S. Gilmour (Lankenau Institute for Medical Research, USA) | Targeting the Immunomodulatory Effects of Polyamines in Cancer |
| 9:35am 10:05am |
[L 12] | M. Azfar (Laboratory of Cellular Transport Systems, Belgium) | ATP13A3 in polyamine homeostasis and in the pathogenesis of Pulmonary Arterial Hypertension |
| 10:05am 10:35am |
[L 13] | T. Murray Stewart (Johns Hopkins University School of Medicine, Baltimore, USA) | Polyamine metabolism in the pathology and treatment of Snyder-Robinson syndrome |
| 10:35am 11:05am |
Coffee break | ||
| 11:05am 11:40am |
[PL 14] | A.S. Bachmann (Michigan State University, USA) | DFMO Treatment of children with ODC-1 linked Bachmann-Bupp Syndrome: from discovery to clinic |
| 11:40am 12:10pm |
[L 15] | E. Agostinelli (Sapienza University of Rome, Italy) | Enzymatic Spermine metabolites induce apoptosis associated with increase of p53, caspase-3 and miR-34a in both Neuroblastoma cells, SJNKP and the N-Myc-Amplified form IMR5 |
| 12:10pm 12:40pm |
[L 16] | G. Weiman (Children’s Cancer Institute, Australia) | Polyamine blockade inhibits cell growth and induces apoptosis in high-risk childhood leukaemia |
| 12:45pm | Photograph | ||
| 1:00pm 2:30pm |
Lunch | ||
| 2:30pm 3:30pm |
Meeting Interational Polyamines Foundation | ||
| 3:30pm 4:00pm |
Oral Poster Presentation | Session leader: P. Mariottini (University ROMA TRE, Rome, Italy) | |
| 4:00pm 5:00pm |
Poster session and Coffee break |
| 5:00pm 6:50pm |
Session 5: POLYAMINES IN NUTRITION AND LONGEVITY | Session leader: P. Mariottini (University ROMA TRE, Rome, Italy) | |
|---|---|---|---|
| 5:00pm 5:30pm |
[L 17] | M. Cervelli (Department of Science, University Roma Tre, Rome, Italy) | Spermidine treatment affects gene expression in mouse model of Amyotrophic Lateral Sclerosis |
| 5:30pm 6:00pm |
[L 18] | T. Uemura (Department of Forensic Medicine, Kyoto Prefectural University of Medicine, Japan) | Aging associated change in polyamine metabolism |
| 6:00pm 6:30pm |
[L 19] | H-J Lin (Department of Bioscience and Biotechnology, Taiwan) | Nutritional value of Spermidine for Strombidium sp. NTOU1, a marine ciliates, and its potential on the ocean food chain and ecosystem |
| 6:30pm 6:50pm |
[L 20] | D. A. Spandidos (University of Crete, Greece) | Publishing in Biochemical science |
| 7:30pm | Dinner |
| 3:30pm 4:00pm |
Oral Poster Presentation | Session leader: P. Mariottini (University ROMA TRE, Rome, Italy) | |
|---|---|---|---|
| 3:30pm 3:45pm |
[P 01] | T. Tahara (Sapienza University of Rome, Italy) | Anti-cancer effect of spermidine inducing autophagy-dependent cell death |
| 3:45pm 4:00pm |
[P 02] | S.van Veen (Laboratory of Cellular Transport System, Belgium) | Quest for the transported of substrate of ATP13A3, a putative polyamine transported linked to neurodevelopmental disorders |
| 9:00am 12:05pm |
Session 6: POLYAMINES AND THEIR ANALOGS:CHEMISTRY AND MOLECULAR PHARMACOLOGY | Session leader: A. R. Khomutov (Russian Academy of Sciences, Russia) | |
|---|---|---|---|
| 9:00am 9:35am |
[PL 21] | U. Bachrach (Hebrew University-Hadassah Medical School, Israel) | The effect of substituted Amino-Alkyl-Anthraquinones on Eukaryotic cells |
| 9:35am 10:05am |
[L 22] | S.Tevosian (Department of Physiological Sciences, University of Florida, USA) | Mechanism of action for an alkylated polyamine analogue diethylnorspermine (DENSPM) in treating pheochromocytoma/paraganglioma |
| 10:05am 10:35am |
[L 23] | R. Ragno (Sapienza University of Rome, Italy) | Ligand-Based and structured-based studies on Polyamine analogues as Bovine Serum Amine Oxidase substrates |
| 10:35am 11:05am |
Coffee Break | ||
| 11:05am 11:35am |
[L 24] | O. Phanstiel (University of Central Florida, Orlando, USA) | Development of FUBP1 inhibitors to control cancer cell growth |
| 11:35am 12:00pm |
[L 27] | U. Bachrach (Hebrew University, Israel) | Green Tea and Polyamines – Past, Present and Future |
| 12:00pm 12:25pm |
[L 25] | M. Houdou (Laboratory of Cellular Transport Systems, Belgium) | Characterization of novel green fluorescent polyamine analogs for measuring polyamine transport of the P5B-type ATPases |
| 12:05pm 1:30pm |
Lunch | ||
| 1:30pm 7:30pm |
Sightseeing | ||
| 8:00pm 10:30pm |
Dinner |
| 9:00am 12:30am |
Session 7: POLYAMINES IN PLANTS AND IN BIOTECHNOLOGICAL APPLICATIONS | Session leader: F. Vianello (University of Padua, Italy) | |
|---|---|---|---|
| 9:00am 9:30am |
[L 26] | A. Mattoo (Sustainable Agricultural Systems Laboratory, USA) | Comparative genomics assisted mapping of polyamine (PA) biosynthetic pathway in duckweed (Spirodela polyrhiza) genome reveals absence of ODC pathway and that PA synthesis genes are differentially regulated during growth, MeJA exposure and salt stress |
| 9:30am 10:00am |
[L 27] | E. Sobieszczuk-Nowicka (Department of Plant Physiology, Poland) | Unravelling the genetics of polyamine metabolism in barley for senescence-related crop improvement |
| 10:00am 10:30am |
[L 27] | M. Arasimowicz-Jelonek (Department of Plant Ecophysiology, Poland) | Genome-wide exploration of genetics of biogenic polyamines in barley |
| 10:30am 11:00am |
Coffee Break | ||
| 11:00am 10:30am |
[L 29] | A. Venerando (Department of Comparative Biomedicine and Food Science, Padua, Italy) | Biotechnological and therapeutic applications of nanostructured hybrids of magnetic nanoparticles conjugated with amine oxidase |
| 11:30pm 12:30pm |
Oral Poster Presentation | Session leader: A.Toninello (University of Padua, Italy) | |
| 1:00pm 2:30pm |
Lunch |
| 3:00Pm 4:30Pm |
Session 8: POLYAMINES METABOLISM, TRANSPORT AND SIGNAL TRANSDUCTION | Session leader: A. Ilari (National Research Council of Italy (CNR), Italy) | |
|---|---|---|---|
| 3:00pm 3:30pm |
[L 30] | N. Ignatenko (University of Arizona, Tucson, USA) | Biotechnological and therapeutic applications of nanostructured hybrids of magnetic nanoparticles conjugated with amine oxidase |
| 3:30pm 4:00pm |
[L 31] | S. van Veen (Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Belgium) | A novel class of polyamine transporters in health and disease |
| 4:00pm 4:30pm |
[L 32] | S. Vrijsen (Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, Belgium) | Elucidating the role of the lysosomal polyamine exporter ATP13A2 in mitochondrial-lysosomal interplay |
| 4:30pm 5:30pm |
Poster session and coffee break |
| 5:30pm 6:30pm |
Session 9: POLYAMINES METABOLISM IN PARASITES AND OTHER MICROORGANISMS | ||
|---|---|---|---|
| 5:30pm 6:00pm |
[L 33] | S. Fujiwara (Department of Bioscience, Kwansei-Gakuin University, Japan) | Identification of unique arginine decarboxylase involved in low pH dependent agmatine production in solid-state cultivated Aspergillus oryzae |
| 6:00pm 6:30pm |
[L 34] | G. Colotti (National research council, CNR, Italy) | Optimization of potent and Specific Trypanothione Reductase Inhibitors: a structure-based drug discovery approach |
| 6:30pm 6:50pm |
Concluding Remarks: E. Agostinelli (SAPIENZA University of Rome, Italy) | ||
|---|---|---|---|
| 8:00pm | Gala Dinner |
| 11:30pm 12:30pm |
Oral Poster Presentation | Session leader: A. Toninello (University of Padua, Italy) | |
|---|---|---|---|
| 3:30pm 3:45pm |
[P 03] | O.Phanstiel (University of Central Florida, USA) | Development of LAT-1 efflux agonists to control pancreatic cancer Cell growth |
| 3:45pm 4:00pm |
[P 04] | G. Weiman (Children’s Cancer Institute, Australia) | Polyamine transporter ATP13A3 is a novel therapeutic target in neuroblastoma |
| 3:45pm 4:00pm |
[P 05] | A. R. Khomutov (Russian Academy of Sciences, Russia) | Phosphorus analogues of AdoMet and AdoHCy: synthesis and interaction with AdoMet decarboxylase and DNA methyltransferase Dnmt3a |
| 3:45pm 4:00pm |
[P 06] | G. Rilievo (University of Padua, Italy) | Functional nanocarrier for bovine serum amine oxidase |
| 9:00 o' clock am | Departure to Fiumicino Airport and Termini Station |
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International Polyamines Foundation Onlus 